Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

The use of conventional drugs for the treatment pain and inflammation has largely resulted in various side effects. These challenges have triggered search alternative therapy such as herbal medication that may serve a safe, effective, alternate approach to managing inflammation. Vitex negundo, potential lipophilic molecule, possesses limited solubility permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with gelling agent form gel delivery active ingredients. Therefore current study is undertaken effective vitex negundo locally emulgel improving was formulated from carbopol 934 mineral oil emulsion using tween 80 (surfactant), triethanolamine (co-surfactant). formulations were optimized design experiment software. formulation containing Smix (tween triethanolamine) ratio 61.90, 50.58%, 3% showed pH 6.5±0.3, viscosity 17793 – 939 cps, spreadability 7.07 g.cm/s. Data in-vitro ex-vivo diffusion studies demonstrated improved permeability properties. stability additionally examined at ambient temperature 28 days. remained stable Based on overall results we can conclude be promising suitable application negundo.